| Player Id | Team | Name | Number | Position | API Id |
|---|---|---|---|---|---|
| 271 | SF | Jimmy Garoppolo | 10 | QB | 16041 |
| 273 | SF | Trey Lance | 5 | QB | 22493 |
| 289 | SF | Nate Sudfeld | 7 | QB | 18104 |
| 283 | SF | Trent Sherfield | 81 | WR | 20081 |
| 296 | SF | Connor Wedington | 83 | WR | 22681 |
| 295 | SF | Austin Watkins Jr. | 14 | WR | 22589 |
| 293 | SF | Austin Mack | 14 | WR | 21862 |
| 291 | SF | River Cracraft | 86 | WR | 19755 |
| 286 | SF | Travis Benjamin | 17 | WR | 13887 |
| 281 | SF | Mohamed Sanu Sr. | 6 | WR | 13878 |
| 280 | SF | Jauan Jennings | 15 | WR | 21717 |
| 270 | SF | Deebo Samuel | 19 | WR | 20932 |
| 275 | SF | Brandon Aiyuk | 11 | WR | 21747 |
| 288 | SF | Raheem Mostert | 31 | RB | 17217 |
| 272 | SF | Elijah Mitchell | 25 | RB | 22535 |
| 294 | SF | Josh Hokit | 40 | RB | 22400 |
| 290 | SF | Brian Hill | 35 | RB | 19033 |
| 276 | SF | Trey Sermon | 28 | RB | 21801 |
| 279 | SF | JaMycal Hasty | 23 | RB | 21765 |
| 277 | SF | Kyle Juszczyk | 44 | RB | 14901 |
| 285 | SF | Trenton Cannon | 49 | RB | 20040 |
| 278 | SF | Jeff Wilson Jr. | 22 | RB | 20360 |
| 287 | SF | Jordan Matthews | 88 | TE | 15974 |
| 284 | SF | Charlie Woerner | 89 | TE | 22119 |
| 292 | SF | Tanner Hudson | 84 | TE | 20506 |
| 274 | SF | George Kittle | 85 | TE | 19063 |
| 282 | SF | Ross Dwelley | 82 | TE | 20361 |
| 29 | SF | SF | 0 | DEF | 31 |